Health disparities are sustained, worsened health outcomes of a specific disadvantaged group. These health differences can be health-related quality of life, rates or severity of disease, disability, mortality, injury, or violence. Disadvantaged populations might be defined by demographic characteristics, disadvantaging environmental conditions, social vulnerability, or geography. For example, the National Institutes of Health has designated the following as United States health-disparity populations: Black/African American, Hispanic/Latino, American Indian/Alaska Native, Asian American, Native Hawaiian and other Pacific Islander, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities.